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KMID : 0380020070220050318
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Korean Journal of Biotechnology and Bioengineering
2007 Volume.22 No. 5 p.318 ~ p.321
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Screening of Photosensitizer for Photodynamic Therapy
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Kim So-Young
Yoo Gui-Jae
Park Keun-Hyoung
Lim Byung-Lak
Chae Hee-Jeong
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Abstract
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Photodynamic therapy (PDT) is a targeted-tumor treatment system using a photosensitizer, light and oxygen to treat malignant tumor. We have investigated the cytotoxicity of 4 types of phthalocyanine derivative (silver phthalocyanine, iron (III) phthalocyanine, copper (II) phthalocyanine, nickel (II) phthalocyanine) against lung and breast cancers based on photodynamic therapy. As a result, phthalocyanine derivatives indicated a higher anticancer activity on a breast cancer cell line. Among the tested phthalocyanines, silver phthalocyanine (AgPc) showed a lower cytotoxicity against a normal cell line. In addition AgPc gave a good color characteristic when it is solubilized in water. Finally AgPc was selected as a potential antitumor agent for breast cancer.
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KEYWORD
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PDT (photodynamic therapy), Photosensitizer, Phthalocyanine
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